![]() Missing data were implicitly imputed by MMRM. Treatment policy strategy (i.e., all observed values used) and hypothetical strategy (i.e., all values censored after the occurrence of the intercurrent event) were applied to non-COVID-19 related and COVID-19 related intercurrent events, respectively. An unstructured covariance structure was used. ≥64 letters), prior intravitreal anti-VEGF therapy (yes vs. For the Mixed Model for Repeated Measures (MMRM) analysis, the model adjusted for treatment arm, visit, visit-by-treatment arm interaction, baseline BCVA (continuous), baseline BCVA (<64 vs. The BCVA letter score ranges from 0 to 100 (best score), and a gain in BCVA letter score from baseline indicates an improvement in visual acuity. ![]() Change From Baseline in BCVA in the Study Eye Over Time, ITT Population īest Corrected Visual Acuity (BCVA) was measured on the Early Treatment Diabetic Retinopathy Study (ETDRS) chart at a starting distance of 4 meters.97.5% confidence interval (CI) is a rounding of 97.52% CI. rest of the world Asia and rest of the world regions were combined). <64 letters), prior IVT anti-VEGF therapy (yes vs. The weighted estimates of the percentage of participants were based on the Cochran-Mantel Haenszel (CMH) weights stratified by baseline BCVA (≥64 vs. ![]() Ocular imaging assessments were made independently by a central reading center. The Early Treatment Diabetic Retinopathy Study (ETDRS) Diabetic Retinopathy Severity Scale (DRSS) classifies diabetic retinopathy into 12 severity steps ranging from absence of retinopathy to advanced proliferative diabetic retinopathy.
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